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Chỉ định và Liều dùng
Nasal
Nasal congestion Adult: As 0.05% soln: 1-2 drops in each nostril up to 6 hrly for 3 days. Child: ≥12 yr Same as adult dose. Ophthalmic Conjunctival decongestant Adult: As 0.1% soln: Instill 1-2 drops onto conjunctival sac 3-4 hrly, as needed. Ophthalmic Minor eye irritation Adult: As 0.012% soln: Instill 1-2 drops into affected eye(s) bid or tid.
Child: ≥12 yr Same as adult dose. |
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Chống chỉ định
Ophth: Narrow-angle glaucoma, corneal damage, acute iritis and other serious eye disease.
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Thận trọng
Patient w/ CV disease, HTN, DM, hyperthyroidism, local infection or injury. Childn. Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Rebound vasodilation or congestion (prolonged/frequent use).
Nervous: Nervousness, headache, drowsiness, dizziness, weakness. GI: Nausea. CV: Cardiac irregularities, HTN. Resp: Burning, stinging, sneezing, increased discharge (nasal). Endocrine: Hyperglycaemia. Ophthalmologic: Mydriasis, ocular hyperaemia, increased redness, irritation, discomfort, blurred vision, punctuate keratitis, lacrimation, increased intraocular pressure. Dermatologic: Sweating. |
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Ophth: C
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Thông tin tư vấn bệnh nhân
This drug may cause drowsiness, temporary blurred vision, and transient mydriasis, if affected, do not drive or operate machinery. Remove contact lenses prior to ophth admin and reinsert after 10-15 min.
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Tương tác
Potentially Fatal: May cause hypertensive crisis w/ MAOI(s).
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Tác dụng
Description:
Mechanism of Action: Naphazoline is an alpha adrenergic receptor agonist which causes vasoconstriction by stimulating arterioles of the conjunctiva and nasal mucosa thus reducing swelling, redness and discomfort when applied to mucous membranes. Onset: Conjunctival vasoconstriction: W/in 10 min. Duration: 2-6 hr. Pharmacokinetics: Absorption: May be absorbed systemically. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Naphazoline, CID=4436, https://pubchem.ncbi.nlm.nih.gov/compound/Naphazoline (accessed on Jan. 22, 2020) |
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Bảo quản
Store below 25°C.
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Phân loại ATC
S01GA01 - naphazoline ; Belongs to the class of sympathomimetics used as ophthalmologic decongestants.
R01AA08 - naphazoline ; Belongs to the class of topical sympathomimetic agents used as nasal decongestants. |
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Tài liệu tham khảo
Anon. Naphazoline (Ophthalmic). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 28/09/2017. Buckingham R (ed). Naphazoline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/09/2017. McEvoy GK, Snow EK, Miller J et al (eds). Naphazoline Hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 28/09/2017. Naphcon Solution (Alcon). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 28/09/2017. Privine Suspension/Drops (Insight Pharmaceuticals LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 28/09/2017.
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