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Chỉ định và Liều dùng
Oral
Oedema Adult: 25-50 mg daily, increase if necessary to 75-100 mg. For long-term therapy: 25-50 mg every 2nd or 3rd day. Oral Hypertension Adult: 25-50 mg daily alone or in combination with other antihypertensives, alternate-day maintenance dosage may be used.
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Chống chỉ định
Severe hepatic or renal impairment; anuria; Addison's disease; hypercalcaemia.
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Thận trọng
Fluid and electrolyte disturbances; hepatic cirrhosis; gout. Elderly; severe heart failure; renal impairment. Monitor blood glucose concentrations in patients taking antidiabetics. Lupus erythematosus. Pregnancy and lactation.
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Tác dụng không mong muốn
Electrolyte imbalance; hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; hypotension; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; dizziness; photosensitivity reactions, postural hypotension, paraesthesia.
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Tương tác
Increased toxicity of digitalis glycosides, allopurinol, tetracyclines. Increased risk of arrhythmia with drugs that prolong the QT interval. Hypotension with other antihypertensives, alcohol, barbiturates, opioids. Increased effects of neuromuscular blockers. Diuretic effects may be antagonised by NSAIDs, corticosteroids, carbenoxolone.
Potentially Fatal: Increased lithium toxicity. |
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Tác dụng
Description:
Mechanism of Action: Mefruside reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of sodium and chloride ions and, therefore, of water. It also reduces the glomerular filtration rate. Onset: 2-4 hrs. |
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Phân loại MIMS
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Đăng xuất
