Menstrual disorders
Adult: 5-10 mg daily as cyclic regimen.
Oral
Contraception
Adult: 0.5 mg daily when used alone or 0.75-2.5 mg daily when used in combination with an oestrogen.
Chỉ định và Liều dùng
Oral
Menstrual disorders Adult: 5-10 mg daily as cyclic regimen. Oral Contraception Adult: 0.5 mg daily when used alone or 0.75-2.5 mg daily when used in combination with an oestrogen.
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Cách dùng
May be taken with or without food.
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Chống chỉ định
Undiagnosed vaginal bleeding, active venous thromboembolic disorders or severe arterial disease, hepatic impairment, progestogen-dependent tumours, porphyria. Pregnancy.
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Thận trọng
CV or renal dysfunction, hypertension, epilepsy, migraine, asthma, DM, conditions which may be exacerbated by fluid retention, malabsorption syndrome, post ectopic pregnancy, functional ovarian cysts, thromboembolism. Lactation.
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Tác dụng không mong muốn
GI disturbances, changes in appetite or weight, fluid retention, oedema, rashes, urticaria, mental depression, breast tenderness and pain, gynaecomastia, changes in libido, headache, migraine, altered menstrual cycle, irregular menstrual bleeding, changes in LFTs and serum lipid profile.
Potentially Fatal: Anaphylaxis or anaphylactoid reactions. |
Tương tác
Increased metabolism and subsequent reduction in efficacy with enzyme-inducing agents e.g. carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Adjustment in antidiabetic dose may be required.
Potentially Fatal: May increase plasma levels and toxicity of ciclosporin. |
Tác dụng
Description:
Mechanism of Action: Lynestrenol is a progestogen structurally related to norethisterone. It may be used alone or as the progestogenic component of some oral contraceptives. |