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Chỉ định và Liều dùng
Oral
Ascariasis Adult: 150 mg as a single dose. Child: 3 mg/kg as a single dose. Oral Ancylostomiasis, Mixed ascariasis-hookworm infections Adult: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases.
Child: 2.5 mg/kg as a single dose, repeated after 7 days in severe cases. |
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Cách dùng
Should be taken with food. Take w/ meals to minimise side effects eg, nausea.
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Chống chỉ định
Preexisting blood disorders; pregnancy and lactation; rheumatoid arthritis; severe renal impairment.
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Thận trọng
Hepatic impairment, Sjogren's syndrome.
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Tác dụng không mong muốn
Nausea, vomiting, diarrhoea, abdominal pain, dizziness and headache. Fever, influenza-like syndrome, arthralgia, muscle pain, rash, taste disturbances and cutaneous vasculitis.
Potentially Fatal: Agranulocytosis, leucopenia, thrombocytopenia. |
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Tương tác
May increase toxicity of phenytoin. Increases bioavailability of ivermectin; decreases bioavailability of albendazole. Alcohol causes disulfiram-like reaction.
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Tác dụng
Description:
Mechanism of Action: Levamisole is the active laevo-isomer of tetramisole. It works by paralysing susceptible intestinal worms which are then excreted from the intestines. Levamisole also enhances cellular immune responses in humans. Pharmacokinetics: Absorption: Well-absorbed from the GI tract. Peak plasma concentrations are achieved in 1.5-2 hr. Metabolism: Occurs extensively in the liver. Excretion: Mainly in the urine (70% as metabolites and 5% as unchanged drug) and small amounts in the faeces. |
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Phân loại MIMS
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Đăng xuất
