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Chỉ định và Liều dùng
Oral
Type 2 diabetes mellitus Adult: 12.5-75 mg daily. Doses ≥50 mg daily are given in 2 divided doses.
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Chống chỉ định
Type 1 diabetes mellitus; ketoacidosis; severe infection; trauma; other severe conditions where glibornuride is unlikely to control the hyperglycaemia; renal or hepatic impairment; porphyria; pregnancy; lactation.
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Thận trọng
Elderly, debilitated or malnourished patients; adrenal or pituitary insufficiency. Monitor blood glucose concentration.
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Tác dụng không mong muốn
GI disturbances; metallic taste; skin rashes, pruritus, photosensitivity; facial flushing; hypoglycaemia; syndrome of inappropriate secretion of antidiuretic hormone; cholestatic jaundice; Stevens-Johnson syndrome; exfoliative dermatitis; erythema nodosum; increased appetite; wt gain; blood disorders.
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Tương tác
Diminished hypoglycaemic effect with adrenaline, aminoglutethimide, chlorpromazine, corticosteroids, diazoxide, oral contraceptives, rifamycins and thiazide diuretics. Increased hypoglycaemic effect with ACE inhibitors, alcohol, allopurinol, some analgesics, azole antifungals, chloramphenicol, cimetidine, clofibrate and related compounds, coumarin anticoagulants, halofenate, heparin, MAOIs, octreotide, ranitidine, sulfinpyrazone, sulfonamides, tetracyclines, tricyclic antidepressants and thyroid hormones. β-blockers increase hypoglycaemia and mask typical sympathetic warning signs.
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Ảnh hưởng đến kết quả xét nghiệm
Altered liver enzyme values.
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Tác dụng
Description:
Mechanism of Action: Glibornuride acts by stimulating insulin secretion and is effective only when some residual pancreatic β-cell activity is present. |
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Phân loại MIMS
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Đăng xuất
