|
Chỉ định và Liều dùng
Oral
Angina pectoris, Cardiac arrhythmias, Hypertension Adult: 25-50 mg every 6-12 hr. Max: 200 mg daily.
|
|
Chống chỉ định
CV shock, complicated acute MI; severe conduction disorders, sick sinus syndrome. Severe renal and hepatic insufficiency. Atrial fibrillation/flutter and simultaneous preexcitation syndrome e.g. Wolff-Parkinson-White syndrome.
|
|
Thận trọng
1st degree AV block, bradycardia <50 beats/min, hypotension <90 mmHg systolic pressure, heart failure (previous compensation with cardiac glycosides/diuretics required). May impair ability to drive or operate machinery. Pregnancy (especially 1st trimester), lactation.
|
|
Tác dụng không mong muốn
Rarely, nausea or vertigo, headache, hypotension, dizziness, flushing, bradycardiac arrhythmias, CHF, AV block. Very rarely, allergic skin reactions; reversible increase in transaminases and/or alkaline phosphatase, constipation; ankle oedema; gingival hyperplasia.
|
|
Tương tác
CV effects enhanced by β-blockers, antiarrhythmics and other drugs with cardiodepressive effects on AV conduction. May intensify BP lowering effect of other antihypertensives. Simultaneous admin of IV β-blockers should be avoided. Digoxin, quinidine, carbamazepine, cimetidine, ranitidine, prazocin, midazolam, lithium, rifampicin, theophylline, phenytoin and phenobarbital may affect the plasma levels of gallopamil, May increase plasma conc of atenolol, metoprolol, propranolol.
|
|
Tác dụng
Description:
Mechanism of Action: Gallopamil is a calcium-channel blocker with antiarrhythmic activity. |
|
Phân loại MIMS
|
Đăng xuất
