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Chỉ định và Liều dùng
Intravenous
Malignant neoplasms of the prostate Adult: As fosfestrol Na: Initially, 600-1,200 mg daily by slow inj over 1 hr to be given for 5-10 days followed by 300 mg daily for 10-20 days. Maintenance: 300-600 mg, reduce gradually over few mth from 4 times wkly to once wkly dosing. Oral Malignant neoplasms of the prostate Adult: As fosfestrol Na: 360-480 mg tid. Maintenance: 120-240 mg tid; may gradually reduce to 240 mg daily.
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Thận trọng
Patient w/ history of heart disease. Hepatic impairment. Pregnancy and lactation.
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Tác dụng không mong muốn
Temporary burning sensation in the perineal region, pain at the site of bony metastases, fluid retention, nausea, arterial and venous thrombosis, breast enlargement in male, impotence, withdrawal bleeding, increased blood Ca level.
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Tác dụng
Description:
Mechanism of Action: Fosfestrol inhibits the action of androgen on prostate gland and also hormone induced growth of cancer cells by competitively binding to the androgen receptors, forming a drug-receptor complex. |
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Bảo quản
Store at room temp.
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Phân loại MIMS
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Phân loại ATC
L02AA04 - fosfestrol ; Belongs to the class of estrogens.
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Tài liệu tham khảo
Buckingham R (ed). Fosfestrol . Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/04/2016.
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