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Chỉ định và Liều dùng
Oral
Male hypogonadism Adult: 5-20 mg daily. Oral Delayed male puberty Child: 2.5-10 mg daily, generally given for 4-6 mth only. Up to 20 mg daily have been used. Oral Palliative treatment of inoperable neoplasms of the breast in postmenopausal women Adult: Up to 40 mg daily.
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Chống chỉ định
Hypersensitivity; males with breast or prostate carcinoma; serious cardiac, renal or hepatic disease. Pregnancy.
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Thận trọng
Cardiac, renal or hepatic dysfunction. Monitor signs of virilization (females) and development of priapism (males). Periodic Hb and haematocrit determinations (high-dose/ long-term therapy). Radiographic exam every 6 mth (prepubertal childn). Child (extreme caution). Lactation. Report too frequent/persistent penile erections; hoarseness, acne, menstrual changes, growth of facial hair (females); nausea, vomiting, changes in skin color, ankle swelling. Discontinue treatment if patient develops jaundice or cholestatic hepatitis. Safety and efficacy of the drug used in enhancing athletic performance is not proven.
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Tác dụng không mong muốn
Acne, gynaecomastia, oedema, hypersensitivity reactions, hypercalcaemia, cholestatic jaundice, fluid and electrolyte retention, changes in libido, anxiety, depression, accelerated bone maturation, clotting factor suppression, male pattern baldness. Oligospermia and decreased ejaculatory vol (males). Amenorrhoea and other menstrual irregularities, gonadotropin secretion inhibition, virilization (females).
Potentially Fatal: Prolonged use is associated with increased risk of hepatic adenoma, hepatocellular carcinoma and peliosis hepatitis. |
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Tương tác
Potentiate action of oral anticoagulants. Coadministration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
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Ảnh hưởng đến kết quả xét nghiệm
Abnormal liver function tests. May decrease protein-bound iodine (PBI) and thyroxine-binding globulin concentrations.
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Tác dụng
Description:
Mechanism of Action: Fluoxymesterone, a synthetic androgenic anabolic steroid hormone, is a halogenated derivative of 17-α-methyltestosterone. It produces nitrogen, K and phosphorus retention; increases protein anabolism; and decreases urinary Ca concentrations, and causes recalcification of osseous metastases and regression of soft tissue lesions. |
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Phân loại MIMS
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Đăng xuất
