Reversal of benzodiazepine-induced sedation
Adult: Anaesthesia: Initially, 0.2 mg via IV inj over 15 seconds; followed by 0.1 mg at 1-minute intervals if needed. Usual dose: 0.3-0.6 mg. Max total dose: 1 mg. Intensive care: Initially, 0.3 mg via IV inj over 15 seconds; followed by 0.1 mg at 1-minute intervals if needed. Max total dose: 2 mg. If drowsiness recurs, give 0.1-0.4 mg/hour via IV infusion then adjust according to the desired level of consciousness. Alternatively, repeat 0.5-1 mg doses may be given at 20-minute intervals if needed up to a Max of 3 mg in any 1-hour period.
Child: >1 year Initially, 0.01 mg/kg (up to 0.2 mg) via IV inj over 15 seconds; may repeat at 1-minute intervals if needed. Max total dose: 0.05 mg/kg or 1 mg (whichever is lower).
Child: >1 year Initially, 0.01 mg/kg (up to 0.2 mg) via IV inj over 15 seconds; may repeat at 1-minute intervals if needed. Max total dose: 0.05 mg/kg or 1 mg (whichever is lower).
Intravenous
Benzodiazepine overdose
Adult: Initially, 0.2 mg via IV inj over 30 seconds; may give further dose of 0.3 mg after 30 seconds and followed by 0.5 mg at 1-minute intervals if needed. Max total dose: 3 mg. In the event of resedation, repeated doses of up to 1 mg may be given at 20-minute intervals if needed up to Max of 3 mg in any 1-hour period.