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Chỉ định và Liều dùng
Ophthalmic
Allergic conjunctivitis Adult: As 0.05% soln: Instill 1 drop into each eye bid.
Child: ≥12 yr Same as adult dose. |
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Thận trọng
Pregnancy and lactation.
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Tác dụng không mong muốn
Nervous: Headache.
GI: Taste disturbance. Resp: Upper resp infection, cough, rhinitis, sinusitis, pharyngitis. Ophthalmologic: Burning sensation, folliculosis, conjunctival hyperaemia, dryness, pain, pruritus, increased lacrimation, visual disturbance. |
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Ophth: C
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Thông tin tư vấn bệnh nhân
Remove contact lenses prior to instillation and may be reinserted after 10-15 min.
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Tác dụng
Description:
Mechanism of Action: Epinastine, a selective H1-receptor antagonist, inhibits the release of histamine from mast cells. It also possesses affinity to H2, α1, α 2, and 5-HT2 receptors. Onset: 3-5 min. Duration: 8 hr. Pharmacokinetics: Absorption: Minimal systemic absorption after topical application. Time to peak plasma concentration: Approx 2 hr. Distribution: Volume of distribution: 417 L. Plasma protein binding: 64%. Metabolism: >10% is metabolised. Excretion: Via urine (as unchanged drug). Terminal elimination half-life: 12 hr. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Epinastine, CID=3241, https://pubchem.ncbi.nlm.nih.gov/compound/Epinastine (accessed on Jan. 22, 2020) |
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Bảo quản
Store between 20-25°C.
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Phân loại MIMS
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Phân loại ATC
S01GX10 - epinastine ; Belongs to the class of other ophthalmologic antiallergics.
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Tài liệu tham khảo
Anon. Epinastine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 28/02/2017. Buckingham R (ed). Epinastine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/02/2017. Epinastine Hydrochloride Solution (Apotex Corp.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 28/02/2017. Joint Formulary Committee. Epinastine Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 28/02/2017. McEvoy GK, Snow EK, Miller J et al (eds). Epinastine Hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 28/02/2017.
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