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Chỉ định và Liều dùng
Oral
Allergic conditions Adult: Usual dose: 10-20 mg once daily. Child: >12 years Same as adult dose. Oral Chronic idiopathic urticaria Adult: 10 mg once daily.
Child: >12 years Same as adult dose. |
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Suy gan
Severe: Max: 10 mg daily.
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Cách dùng
May be taken with or without food.
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Thận trọng
Patient with cardiac risks (e.g. long QT syndrome, hypokalaemia, treatment with agents known to increase QT interval). Concomitant use with CYP3A4 inhibitors. Severe hepatic impairment. Children. Pregnancy and lactation.
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Tác dụng không mong muốn
Cardiac disorders: Rarely, palpitation, tachycardia.
Gastrointestinal disorders: Dry mouth. Rarely, dysgeusia, abdominal pain, nausea, dyspepsia, vomiting. General disorders and administration site conditions: Asthenia. Hepatobiliary disorders: Rarely, hepatitis, cholestasis. Immune system disorders: Rarely, hypersensitivity reactions (e.g. angioedema, anaphylaxis). Investigations: Rarely, abnormal LFTs. Nervous system disorders: Headache, drowsiness. Rarely, dizziness, hypoesthesia. Psychiatric disorders: Rarely, nervousness, insomnia. Reproductive system and breast disorders: Rarely, menstrual disorders. Respiratory, thoracic and mediastinal disorders: Pharyngitis, sinusitis, epistaxis. |
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Thông tin tư vấn bệnh nhân
This drug may cause drowsiness or sometimes dizziness; if affected, do not drive or operate machinery.
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Tương tác
Increased plasma levels and risk of QTc interval prolongation with ketoconazole, itraconazole and erythromycin. Plasma concentrations and antihistamine effects may be decreased by rifampicin.
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Tương tác với thức ăn
Plasma levels of carebastine may be increased by 1.5-2 fold with food.
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Ảnh hưởng đến kết quả xét nghiệm
May interfere with allergy skin test results.
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Tác dụng
Description:
Mechanism of Action: Ebastine, a piperidine derivative, is a long-acting, non-sedating antihistamine that selectively binds to histamine H1 receptors to inhibit the effects of histamines. Pharmacokinetics: Absorption: Rapidly absorbed from the gastrointestinal tract. Food may increase the plasma levels of carebastine (active metabolite). Time to peak plasma concentration: Approx 2-4 hours (carebastine). Distribution: Plasma protein binding: >95%. Metabolism: Almost completely metabolised primarily by CYP3A4 isoenzyme into carebastine; undergoes extensive hepatic and intestinal first-pass metabolism. Excretion: Via urine (66%, primarily as conjugated metabolites). Elimination half-life: 15-19 hours (carebastine). |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 3191, Ebastine. https://pubchem.ncbi.nlm.nih.gov/compound/Ebastine. Accessed Nov. 24, 2020. |
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Bảo quản
Store below 30°C.
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Phân loại MIMS
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Phân loại ATC
R06AX22 - ebastine ; Belongs to the class of other antihistamines for systemic use.
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Tài liệu tham khảo
Anon. Ebastine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 01/09/2020. Buckingham R (ed). Ebastine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 01/09/2020. Ebast-DT 5 mg Dispersible Tablet (Brown & Burk Philippines, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 01/09/2020. Kestine 10 mg Film-Coated Tablet (Zuellig Pharma Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my/. Accessed 17/11/2020.
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