Hypersensitivity reactions
Adult: Up to 25 mg 4-6 hrly. Max: 150 mg daily.
Oral
Short-term management of insomnia
Adult: 25 mg given 30 min before bedtime.
Chỉ định và Liều dùng
Oral
Hypersensitivity reactions Adult: Up to 25 mg 4-6 hrly. Max: 150 mg daily. Oral Short-term management of insomnia Adult: 25 mg given 30 min before bedtime.
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Cách dùng
Should be taken with food. Take w/ food or milk.
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Chống chỉ định
Lactation.
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Thận trọng
Patient w/ increased intraocular pressure/glaucoma, urinary retention, prostate enlargement, pyloroduodenal obstruction, thyroid dysfunction, resp disease, epilepsy or severe CV disorder (e.g. HTN, ischaemic heart disease). Pregnancy.
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Tác dụng không mong muốn
CNS depression, stimulation (e.g. insomnia, nervousness, euphoria, irritability, tremors, nightmares, hallucinations, convulsions); headache, lack of coordination, dizziness, psychomotor impairment, constipation, nausea, vomiting, diarrhoea, increased gastric reflux, epigastric pain, thickened resp tract secretions, dry mouth, palpitations, arrhythmias, blurred vision, urinary retention, blood disorders, hypotension, tinnitus, paraesthesia, hypersensitivity reactions.
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PO: B (FDA Pregnancy Category A applies to doxylamine succinate w/ pyridoxine hydrochloride.)
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Thông tin tư vấn bệnh nhân
This drug may cause drowsiness, if affected, do not drive or operate machinery.
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Quá liều
Symptoms: Dry mouth, fixed and dilated pupils, flushing, GI symptoms, insomnia, nervousness, euphoria, irritability, tremors, nightmares, hallucinations, CNS depression or stimulation (esp in child), impaired consciousness, seizures, tachycardia, mydriasis, psychosis, rhabdomyolysis, coma and cardiorespiratory arrest. Management: Supportive and symptomatic treatment. Ensure adequate ventilation and hydration. Perform gastric lavage or administer activated charcoal w/in 60 min of ingestion. Whole bowel irrigation w/ polyethylene glycol electrolyte may be given to patients w/ extremely large ingestions.
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Tương tác
Additive effect when administered w/ other CNS depressants (e.g. opioids analgesics, neuroleptics, hypnotics, other psychotherapeutic drugs). Antimuscarinic effects may be enhanced by MAOIs. May decrease emetic response to apomorphine. Additive antimuscarinic effects w/ other antimuscarinic drugs (e.g. atropine, TCAs).
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Tương tác với thức ăn
May enhance the CNS depressant effect of alcohol.
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Ảnh hưởng đến kết quả xét nghiệm
May cause false-positive reaction in urine detection of methadone. May suppress positive skin test results.
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Tác dụng
Description:
Mechanism of Action: Doxylamine, an ethanolamine derivative antihistamine, competitively blocks histamine at H1-receptor sites. It also diminishes vestibular stimulation and depresses labyrinthine function through its central anticholinergic activity. Duration: 6-8 hr. Pharmacokinetics: Absorption: Absorbed easily from the GI tract. Time to peak plasma concentration: 2-4 hr. Distribution: Enters breast milk (small amount). Volume of distribution: 2.5 L/kg. Metabolism: Metabolised hepatically via N-dealkylation to form metabolites. Excretion: Via urine, 60% as unchanged drug. Elimination half-life: 10-12 hr. |
Đặc tính
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Bảo quản
Store between 15-30°C.
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Phân loại MIMS
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Phân loại ATC
R06AA09 - doxylamine ; Belongs to the class of aminoalkyl ethers used as systemic antihistamines.
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Tài liệu tham khảo
Anon. Doxylamine . Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/10/2016. Buckingham R (ed). Doxylamine Succinate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com . Accessed 18/10/2016. McEvoy GK, Snow EK, Miller J et al (eds). Doxylamine Succinate. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 18/10/2016. Nighttime Sleep Aid (Wal-Mart Stores Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 18/10/2016. Wilson Consumer Products. Dozile Capsules data sheet 16 July 2008. Medsafe. http://www.medsafe.govt.nz/. Accessed 18/10/2016.
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