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Chỉ định và Liều dùng
Ophthalmic
Dry eye Adult: As 3% diquafosol sodium solution: Instill 1 drop into the affected eye(s) 6 times daily.
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Tác dụng không mong muốn
Eye disorders: Eye irritation, eye discharge, conjunctival hyperaemia, eye pain, eye itching, foreign body sensation in eyes, ocular discomfort, increased lacrimation, blepharitis, hyposphagma, photophobia, blurred vision, corneal epithelium disorder (e.g. keratitis superficial, corneal erosion), conjunctivitis.
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Thông tin tư vấn bệnh nhân
This drug may cause blurred vision, if affected, do not drive or operate machinery. Remove contact lenses prior to administration and reinsert after 15 minutes.
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Tác dụng
Description:
Mechanism of Action: Diquafosol acts on the P2Y2 receptors on the conjunctival epithelium and goblet cell membranes thereby increasing intracellular Ca ion concentration promoting water and mucin secretion. Pharmacokinetics: Metabolism: Rapidly metabolised to uridine-5’-monophosphate, uridine and uracil. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Diquafosol, CID=148197, https://pubchem.ncbi.nlm.nih.gov/compound/Diquafosol (accessed on Jan. 21, 2020) |
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Bảo quản
Store below 30°C.
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Phân loại MIMS
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Tài liệu tham khảo
Mun Y, Kwon JW, Oh JY. Therapeutic Effects of 3% Diquafosol Ophthalmic Solution in Patients with Short Tear Film Break-up Time-type Dry Eye Disease. BMC Ophthalmology. 2018;18:237. doi: 10.1186/s12886-018-0910-3. Accessed 18/10/2019 Nam K, Kim HJ, Yoo A. Efficacy and safety of topical 3% diquafosol ophthalmic solution for the treatment of multifactorial dry eye disease: meta-analysis of randomized clinical trials. Ophthalmic Res. 2019 Jan;61(4):188-198. doi: 10.1159/000492896. Accessed 18/10/2019. PMID: 30654362 Buckingham R (ed). Diquafosol Tetrasodium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/10/2019. Diquas 3% Solution (Santen Pharma Malaysia Sdn. Bhd.). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 18/10/2019. Diquas 3% Solution (Santen Philippines Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 18/10/2019.
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Đăng xuất
