Pregnancy termination in the 2nd trimester
Adult: 40 mg by slowly injecting 8 ml of solution containing 5 mg/ml into the amniotic sac; give a further dose of 10-40 mg after 24 hr if the membranes are still intact.
Chỉ định và Liều dùng
Intra-amniotic
Pregnancy termination in the 2nd trimester Adult: 40 mg by slowly injecting 8 ml of solution containing 5 mg/ml into the amniotic sac; give a further dose of 10-40 mg after 24 hr if the membranes are still intact.
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Chống chỉ định
Pelvic infection; history of pelvic inflammatory disease. Active cardiac, pulmonary, renal or hepatic disease. Smoker.
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Thận trọng
Glaucoma or raised intraocular pressure, asthma or a history of asthma, epilepsy or a history of epilepsy, hepatic or renal dysfunction, CV disease. Do not administer by the myometrial route. Do not administer by the extraamniotic route in patients with cervicitis or vaginal infections. Monitor uterine activity, foetal status, cervical dilatation progress. In the induction of labor, carefully evaluate cephalopelvic relationships before use. Possibility of uterine rupture. Caution in patients with membrane rupture.
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Tác dụng không mong muốn
Bronchoconstriction; nausea; vomiting; diarrhoea; abdominal pain; flushing; shivering; headache; dizziness; hypotension; sudden CV collapse; hypertension; hypersensitivity reactions; convulsions; EEG changes; local tissue irritation; erythema; pyrexia; raised white cell count; local infection; excessive uterine activity; uterine rupture; cervical laceration and rupture; foetal distress and rarely fetal death.
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Tương tác
Potentiates uteronic effect of oxytocin.
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Tác dụng
Description:
Mechanism of Action: Dinoprost is a prostaglandin with actions on smooth muscles. It induces contraction of uterine muscles and acts predominantly as a vasoconstrictor on blood vessels and a bronchoconstrictor on bronchial muscles. |
Phân loại MIMS
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