Do not apply on the face, eyes, mucous membranes, intertriginous areas, occluded or broken skin, and into a large surface area.
Chỉ số theo dõi
Monitor for hypothalamic-pituitary adrenal (HPA) axis suppression through ACTH stimulation test, plasma cortisol test, or urinary free cortisol test.
Tác dụng
Description: Mechanism of Action: Diflorasone is a glucocorticoid that has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, hence depresses the formation, release, and activity of chemical inflammatory mediators. Pharmacokinetics: Absorption: Absorbed through normal intact skin (approx 1%); increased percutaneous absorption in inflamed or occluded skin. Metabolism: Metabolised in the liver. Excretion: Via urine and faeces.
Đặc tính
Source: National Center for Biotechnology Information. PubChem Database. Diflorasone, CID=71415, https://pubchem.ncbi.nlm.nih.gov/compound/Diflorasone (accessed on Jan. 21, 2020)
D07AC10 - diflorasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
Tài liệu tham khảo
Anon. Diflorasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/02/2017.Buckingham R (ed). Diflorasone Diacetate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/02/2017.Diflorasone Diacetate Cream (E. Fougera & Co. A division of Fougera Pharmaceuticals Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/02/2017.McEvoy GK, Snow EK, Miller J et al (eds). Dilforasone Diacetate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 16/02/2017.
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