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Chỉ định và Liều dùng
Oral
Filariasis, Loiasis, Toxocariasis Adult: Initially, 1 mg/kg daily, increased gradually to 6 mg/kg daily over 3 days then maintained for 3 wk. A corticosteroid may be given concurrently for the treatment of filarial infections. Oral Prophylaxis of loiasis Adult: 300 mg wkly.
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Chống chỉ định
Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease.
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Thận trọng
Patients with poor health.
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Tác dụng không mong muốn
Fever, headache, vomiting, dizziness, drowsiness, nausea, chills.
Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage. |
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Tác dụng
Description:
Mechanism of Action: Diethylcarbamazine is an anthelmintic that is used in the treatment of lymphatic filariasis. It is active against the microfilariae and adult worms of W. bancrofti, B. malayi, B. timori and Loa loa but only against the microfilariae of O. volvulus. It is also used in treatment of toxocariasis. Repeated courses may be necessary. Pharmacokinetics: Absorption: Readily absorbed from the GI tract (oral); skin (topical); conjunctiva (optical). Distribution: Widely distributed in tissues. Excretion: Urine (as unchanged drug and N-oxide metabolite). |
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Bảo quản
Store below 30°C.
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Phân loại MIMS
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Đăng xuất
