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Chỉ định và Liều dùng
Oral
Osteoarthritis Adult: Usual dose: 50 mg bid. Alternatively, 50 mg once daily with evening meal for 2-4 weeks. Dose may be increased to 100 mg daily in divided doses according to patient tolerability. Treatment duration may vary according to patient response and expected clinical outcome.
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Suy thận
Severe: Contraindicated.
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Suy gan
Severe: Contraindicated.
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Cách dùng
Should be taken with food. Take w/ or immediately after meals.
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Chống chỉ định
Hypersensitivity to anthraquinone derivatives. Inflammatory intestinal disease (e.g. ulcerative colitis, Crohn’s disease), intestinal obstruction, painful abdominal syndromes of undetermined cause. Severe renal and hepatic impairment. Concomitant use with laxatives.
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Thận trọng
Patient with previous episode of enterocolic disturbances (e.g. irritable bowel syndrome). Elderly. Moderate renal and mild to moderate hepatic impairment. Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Diarrhoea.
Gastrointestinal disorders: Abdominal pain, flatulence. Hepatobiliary disorders: Hepatitis. Investigations: Elevated liver enzymes. Renal and urinary disorders: Dark yellow coloured urine. Skin and subcutaneous tissue disorders: Pruritus, rash, eczema. |
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Quá liều
Symptoms: Diarrhoea. Management: Restore hydroelectrolytic balance if necessary.
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Tương tác
Reduced bioavailability with aluminium hydroxide, magnesium hydroxide or calcium-based antacids. Increased risk of enterocolic events with antibiotics (e.g. amoxicillin/clavulanic acid) and/or chemotherapy. Increased risk of dehydration and hypokalaemia with diuretics. Increased risk of arrhythmia with cardiac glycosides (e.g. digitoxin, digoxin).
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Tương tác với thức ăn
Increased absorption with food.
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Tác dụng
Description:
Mechanism of Action: Diacerein is an anthraquinone derivative and a prodrug that is metabolised to rhein, a selective inhibitor of interleukin-1 (IL-1). It increases the production of transforming growth factor-β (TGF-β) which triggers chondrocyte proliferation and stimulates the production of collagen and proteoglycan. Pharmacokinetics: Absorption: Well absorbed from the gastrointestinal tract. Food, increases absorption. Time to peak plasma concentration: 15-30 minutes (rhein). Distribution: Plasma protein binding: Approx 99% (rhein). Metabolism: Extensively metabolised in the liver to active metabolite, rhein. Excretion: Mainly via urine (20% [as unchanged drug], 60% [as glucuronide], 20% [as sulfate derivatives]). Elimination half-life: 7-8 hours. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 26248, Diacerein. https://pubchem.ncbi.nlm.nih.gov/compound/Diacerein. Accessed Aug. 25, 2020. |
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Bảo quản
Store below 30°C. Protect from light and moisture.
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Phân loại MIMS
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Phân loại ATC
M01AX21 - diacerein ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
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Tài liệu tham khảo
Anon. Diacerein. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/08/2020. Artrodar 50 mg (TRB Pharma S.A.). MIMS Thailand. http://www.mims.com/thailand. Accessed 07/08/2020. Buckingham R (ed). Diacerein. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/08/2020. Tirase Capsules 50 mg (Elder Pharmaceuticals Ltd). MIMS Myanmar. http://www.mims.com/myanmar. Accessed 07/08/2020.
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