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Chỉ định và Liều dùng
Topical/Cutaneous
Corticosteroid-responsive dermatoses Adult: As 0.05-0.25% cream/gel/lotion/oint: Apply a thin film onto affected area bid. Rub in gently. Child: Same as adult dose. Topical/Cutaneous Plaque psoriasis Adult: As 0.25% spray: Apply a thin film onto affected area bid. Rub in gently.
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Thận trọng
Childn. Pregnancy and lactation.
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Tác dụng không mong muốn
Atrophy, striae, telangiectasias, burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentations, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, miliaria. Reversible HPA axis suppression, Cushing’s syndrome, hyperglycaemia, unmasking of latent DM (from systemic absorption).
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Topical: C
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Thông tin tư vấn bệnh nhân
Avoid use of occlusive dressings. Topical spray is flammable, avoid exposure to heat and flame or smoking during or immediately after application.
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Chỉ số theo dõi
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression through ACTH stimulation or urinary free cortisol test.
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Tương tác
May diminish the antineoplastic effect of aldesleukin. May potentiate the hyperglycaemic effect of ceritinib. May diminish the therapeutic effect of corticorelin and hyaluronidase. May enhance the adverse/toxic effects of deferasirox.
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Tác dụng
Description:
Mechanism of Action: Desoximetasone is a topical corticosteroid that induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid hence depresses the formation, release, and activity of endogenous chemical mediators such as kinins, histamine, liposomal enzymes, and prostaglandins. Pharmacokinetics: Absorption: Absorbed through normal skin; increased percutaneous absorption in traumatised or inflamed skin. Metabolism: Metabolised in the liver. Excretion: Via urine and faeces. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Desoximetasone, CID=5311067, https://pubchem.ncbi.nlm.nih.gov/compound/Desoximetasone (accessed on Jan. 20, 2020) |
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Bảo quản
Store between 20-25°C. Spray: Protect from heat or flame.
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Phân loại MIMS
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Phân loại ATC
D07AC03 - desoximetasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
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Tài liệu tham khảo
Anon. Desoximetasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 23/11/2016. Buckingham R (ed). Desoximetasone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 23/11/2016. Desoximetasone Cream (Perrigo New York Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016. Desoximetasone Ointment (Teligent Pharma, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016. McEvoy GK, Snow EK, Miller J et al (eds). Desoximetasone (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 23/11/2016. Topicort Ointment USP 0.05% (Taro Pharmaceuticals Inc) . U.S. FDA. https://www.fda.gov/. Accessed 23/11/2016. Topicort Spray (Taro Pharmaceuticals U.S.A., Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016.
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