Hypertension
Adult: 10-20 mg once-bid, increased by 10-20 mg every 3 or 4 days according to severity of condition. Maintenance: 20-120 mg daily.
Chỉ định và Liều dùng
Oral
Hypertension Adult: 10-20 mg once-bid, increased by 10-20 mg every 3 or 4 days according to severity of condition. Maintenance: 20-120 mg daily.
|
Chống chỉ định
Phaeochromocytoma, heart failure.
|
Thận trọng
Renal impairment, coronary or cerebral arteriosclerosis, asthma, history of peptic ulceration, pregnancy. Abrupt cessation may lead to rebound hypertension.
|
Tác dụng không mong muốn
Postural hypotension, failure of ejaculation, fluid retention, nasal decongestion, headache, diarrhoea, drowsiness.
|
Tương tác
Adrenaline, amfetamine, other sympathomimetics, TCAs, MAOIs, phenothiazine derivatives and related antipsychotics, oral contraceptives, digoxin or other digitalis derivatives, thiazide diuretics, other antihypertensives, levodopa, alcohol.
|
Tác dụng
Description:
Mechanism of Action: Debrisoquine acts by selectively inhibiting transmission in postganglionic adrenergic nerves. It acts mainly by preventing the release of noradrenaline at nerve endings. It does not prevent the catecholamine secretion by the adrenal medulla. Onset: 4-10 hr. Duration: 9-24 hr. Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract. Metabolism: Main metabolite: 4-hydroxydebrisoquine. |
Phân loại MIMS
|