Hypertension
Adult: 0.25-0.5 mg daily alone or in conjunction with other antihypertensives.
Oral
Oedema
Adult: Initial: 0.25-0.5 mg daily, reduce to lowest effective dose for maintenance. Up to 1 mg daily in patients with heart failure.
Chỉ định và Liều dùng
Oral
Hypertension Adult: 0.25-0.5 mg daily alone or in conjunction with other antihypertensives. Oral Oedema Adult: Initial: 0.25-0.5 mg daily, reduce to lowest effective dose for maintenance. Up to 1 mg daily in patients with heart failure.
|
Chống chỉ định
Severe hepatic or renal impairment; anuria; Addison's disease; hypercalcaemia; porphyria.
|
Thận trọng
Fluid and electrolyte disturbances; hepatic cirrhosis; gout; DM. Elderly; severe heart failure; renal or hepatic impairment. Monitor blood glucose concentrations in patients on antidiabetics. Pregnancy, lactation.
|
Tác dụng không mong muốn
Electrolyte imbalance; hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; hypotension; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; glycosuria; dizziness; photosensitivity reactions, postural hypotension, paraesthesia.
|
Tương tác
Digitalis glycosides; drugs that prolong QT interval; other antihypertensives; competitive muscle relaxants; pressor amines; corticosteroids, corticotrophin; β2-agonists, α-blockers; ACE inhibitors; NSAIDs; alcohol, barbiturates; opioids; lithium; allopurinol; tetracyclines; carbenoxolone; hypoglycaemics.
|
Tác dụng
Description:
Mechanism of Action: Cyclopenthiazide reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of Na and chloride ions and consequently of water. It also reduces the glomerular filtration rate. Onset: 1-3 hr. Duration: About 12 hr. |
Phân loại MIMS
|