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Chỉ định và Liều dùng
Topical/Cutaneous
Atopic dermatitis Adult: For the treatment of mild to moderate cases: As 2% ointment: Apply a thin layer to the affected area(s) bid.
Child: ≥3 months Same as adult dose. |
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Thận trọng
Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Hypersensitivity reactions (e.g. contact urticaria).
General disorders and administration site conditions: Application site pain (e.g. mild transient burning or stinging). Skin and subcutaneous tissue disorders: Allergic contact dermatitis. |
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Chỉ số theo dõi
Monitor for signs of hypersensitivity reactions.
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Tác dụng
Description:
Mechanism of Action: Crisaborole inhibits phosphodiesterase 4 (PDE-4) which causes an increase in intracellular cyclic adenosine monophosphate (cAMP) levels, a modulator of inflammatory responses. Although it acts as an anti-inflammatory agent, the exact mechanism for its effect on the treatment of atopic dermatitis has not been fully elucidated. Pharmacokinetics: Absorption: Rapidly absorbed systemically after topical application. Distribution: Plasma protein binding: 97%. Metabolism: Metabolised in the liver via hydrolysis into inactive major metabolite, 5-(4-cyanophenoxy)-2-hydroxyl benzylalcohol; this metabolite is metabolised further via oxidation into downstream metabolites, among which includes another major metabolite, 5-(4-cyanophenoxy)-2-hydroxyl benzoic acid. Excretion: Via urine (as inactive metabolites). |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 44591583, Crisaborole. https://pubchem.ncbi.nlm.nih.gov/compound/Crisaborole. Accessed Feb. 23, 2021. |
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Bảo quản
Store between 15-30°C.
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Phân loại MIMS
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Phân loại ATC
D11AH06 - crisaborole ; Belongs to the class of agents for atopic dermatitis, excluding corticosteroids. Used in the treatment of atopic dermatitis.
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Tài liệu tham khảo
Anon. Crisaborole. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 05/02/2021. Anon. Crisaborole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 26/05/2023. Buckingham R (ed). Crisaborole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/02/2021. Crisaborole. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 26/05/2023. Eucrisa (Pfizer Laboratories Div Pfizer Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 26/05/2023. Eucrisa Ointment (Pfizer Labs). U.S. FDA. https://www.fda.gov. Accessed 26/05/2023.
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