|
Chỉ định và Liều dùng
Oral
Premedication before anaesthesia Adult: 100 mcg/kg as a single dose. Elderly: Dose reduction may be necessary. Oral Short-term management of anxiety Adult: Up to 12 mg/day in divided doses.
Elderly: Dose reduction may be necessary. |
|
Chống chỉ định
Preexisting CNS depression or coma, respiratory depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; not indicated for chronic psychosis, phobic or obsessional states; may precipitate suicide or aggressive behavior, not to be used alone to treat depression or anxiety associated with depression; glaucoma.
|
|
Thận trọng
Chronic pulmonary insufficiency; elderly or debilitated patients; muscle weakness, impaired liver or kidney function; drowsiness may affect skilled tasks; monitor cardio-respiratory function when used for deep sedation; patients with personality disorders or organic brain changes; pregnancy and lactation; history of alcohol or drug addiction due to risk of dependence. Respiratory depression and hypotension with parenteral admin, therefore this route should only be used when facilities for reversing respiratory depression are available.
|
|
Tác dụng không mong muốn
Drowsiness, sedation, muscle weakness and ataxia; less frequently vertigo, headache, confusion, depression, slurred speech, changes in libido, tremor, visual disturbances, urinary retention, GI disturbances, changes in salivation and amnesia.
|
|
Tương tác
Enhanced sedation or respiratory and CV depression with drugs that have CNS depressant properties e.g. antidepressants, antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, opioid analgesics and cisapride. Alcohol.
Potentially Fatal: Drugs which alter the hepatic microsomal enzymes. |
|
Tác dụng
Description:
Mechanism of Action: Cloxazolam is a long-acting benzodiazepine with general properties similar to diazepam. It is used in the short-term treatment of anxiety disorders. |
|
Phân loại MIMS
|
Đăng xuất
