Adult: As 0.05% ointment/cream: Apply thinly and rub gently onto the affected area once daily or bid, gradually discontinue once control is achieved. Max treatment duration: 4 weeks. Child: Same as adult dose. Max treatment duration: 7 days.
Chống chỉ định
Untreated cutaneous infections of bacterial, fungal, treponemal, tuberculous, or viral origin; acne vulgaris, pruritus without inflammation, perioral dermatitis, rosacea.
Thận trọng
Patient with psoriasis, stasis dermatitis. Not recommended for long-term use (particularly on the face). Children and elderly. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: HPA axis suppression (e.g. Cushingoid features, hyperglycaemia, glycosuria), allergic contact dermatitis, bacterial or fungal superinfection, increased risk of posterior subscapular cataracts and glaucoma. Eye disorders: Blurred vision, visual disturbance. Skin and subcutaneous tissue disorders: Pruritus.
Thông tin tư vấn bệnh nhân
Avoid application to the face, scalp, groin, genitals, axilla, or between toes without medical advice. Avoid contact with eyes. Do not use occlusive dressing. Avoid abrupt withdrawal.
Chỉ số theo dõi
Monitor for adrenal insufficiency and HPA axis suppression. Assess for signs and symptoms of visual disturbances.
Quá liều
Symptoms: Hypercortisolism or Cushing’s syndrome (e.g. moon face, buffalo hump, hirsutism, weight gain), and HPA axis suppression. Management: Withdraw clobetasone gradually by decreasing the frequency of application or use less potent corticosteroids.
Tương tác
Increased systemic exposure with CYP3A4 inhibitors (e.g. ritonavir, itraconazole).
Tác dụng
Description: Mechanism of Action: Clobetasone is a moderately potent corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive properties. It induces phospholipase A2 inhibitory proteins (lipocortins) thereby depressing the formation, release, and activity of endogenous chemical mediators of inflammation (e.g. histamine, kinase, liposomal enzymes, prostaglandins). It also decreases the density of mast cells, chemotaxis, activation of eosinophils, and cytokine production, and inhibits the metabolism of arachidonic acid. Pharmacokinetics: Absorption: May be systematically absorbed from intact healthy skin. Metabolism: Metabolised in the liver. Excretion: Via urine and bile.