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Chỉ định và Liều dùng
Oral
Allergic conditions Adult: 25 mg 6-8 hrly. Max: 75 mg 24 hrly. Child: 6-11 yr 12.5 mg 6-8 hrly. Max: 37.5 mg 24 hrly; ≥12 yr Same as adult dose. Oral Motion sickness Child: ≥6 yr As chewable tab: 25 mg 6-8 hrly taken up to 1 hr before travel or at onset of symptoms.
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Chống chỉ định
Emphysema, chronic bronchitis, glaucoma, enlarged prostate gland.
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Thận trọng
Childn. Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Drowsiness, excitability.
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Thông tin tư vấn bệnh nhân
This drug may cause drowsiness, if affected, do not drive or operate machinery.
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Tương tác
May enhance the action of epinephrine.
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Tác dụng
Description:
Mechanism of Action: Chlorcyclizine, a piperazine derivative, is a sedating antihistamine given for the symptomatic relief of hypersensitivity reactions. Additionally, it has some local anaesthetic, anticholinergic, antiserotonergic properties, and can be used as an antiemetic. Pharmacokinetics: Absorption: Readily absorbed. Time to peak plasma concentration: 5 hr. Distribution: Widely distributed throughout the body. Plasma protein binding: 85-90%. Metabolism: Metabolised via N-demethylation to norchlorcyclizine and via N-oxidation to chlorcyclizine N-oxide. Excretion: Via urine (as norchlorcyclizine and approx 0.5% as chlorcyclizine N-oxide). |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Chlorcyclizine, CID=2710, https://pubchem.ncbi.nlm.nih.gov/compound/Chlorcyclizine (accessed on Jan. 21, 2020) |
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Bảo quản
Store between 20-25°C.
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Phân loại MIMS
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Phân loại ATC
R06AE04 - chlorcyclizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.
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Tài liệu tham khảo
Ahist Tablet (Magna Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/02/2017. Bonine Kids Tablet, Chewable (Insight Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/02/2017. Buckingham R (ed). Chlorcyclizine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/02/2017. Chlorcyclizine. National Center for Biotechnology Information. PubChem Database. https://pubchem.ncbi.nlm.nih.gov/. Accessed 21/02/2017.
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