Lower respiratory tract infections, Urinary tract infections
Adult: 1-2 g every 12 or 24 hr via IM or IV infusion. Up to 4 g/day may be used in severe infections.
Parenteral
Gonorrhoea
Adult: 0.25-0.5 g as a single dose given by IM or IV infusion.
Chỉ định và Liều dùng
Parenteral
Lower respiratory tract infections, Urinary tract infections Adult: 1-2 g every 12 or 24 hr via IM or IV infusion. Up to 4 g/day may be used in severe infections. Parenteral Gonorrhoea Adult: 0.25-0.5 g as a single dose given by IM or IV infusion.
|
||||||
Suy thận
Parenteral:
Lower respiratory tract infections, Urinary tract infections: In patients undergoing dialysis: 0.5-1 g daily is given after dialysis.
|
||||||
Chống chỉ định
Hypersensitivity to cephalosporins.
|
||||||
Thận trọng
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and haematologic status. Pregnancy, lactation.
|
||||||
Tác dụng không mong muốn
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; pseudomembranous colitis; hepatic dysfunction; haematologic disorders; pain at inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
|
||||||
Tương tác
Renal clearance reduced by probenecid.
|
||||||
Ảnh hưởng đến kết quả xét nghiệm
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; positive reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
|
||||||
Tác dụng
Description:
Mechanism of Action: Cefodizime has uses similar to cefotaxime, but without active metabolite. It has variable activity against Citrobacter spp., and P. aeruginosa and B. fragilis are generally resistant. Pharmacokinetics: Distribution: About 80% bound to plasma proteins. Widely distributed into body tissues and fluids. Crosses the placenta and detected in breast milk. Excretion: Terminal elimination half-life of about 4 hr. Mainly excreted unchanged in the urine. |
||||||
Phân loại MIMS
|