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Chỉ định và Liều dùng
Parenteral
Susceptible infections Adult: 1-4 g daily IM/IV by Inj or infusion in 2-4 divided doses, up to 9 g daily for severe infections.
Child: 40-80 mg/kg/day in 2-4 divided doses, higher doses may be used in severe infections. Neonates: 40-60 mg/kg/day in 2-3 divided doses. |
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Chống chỉ định
Hypersensitivity to cephalosporins.
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Thận trọng
Hypersensitivity to penicillins; renal impairment; porphyria. Monitor renal and hematologic status. Pregnancy and lactation.
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Tác dụng không mong muốn
Nausea; vomiting; diarrhoea; hypersensitivity reactions; nephrotoxicity; convulsions; CNS toxicity; hepatic dysfunction; haematologic disorders; pain at Inj site (IM); thrombophloebitis (IV infusion); superinfection with prolonged use.
Potentially Fatal: Pseudomembranous colitis. |
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Tương tác
Renal clearance reduced by probenecid. Disulfiram-like reactions with alcohol.
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Ảnh hưởng đến kết quả xét nghiệm
Positive direct antiglobulin Coombs' test; falsely high values with Jaffe method of measuring creatinine concentrations; +ve reactions for false glucose using copper-reduction reactions; transient increases in liver enzyme values.
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Tác dụng
Description:
Mechanism of Action: Cefmenoxime inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is highly stable to hydrolysis by most β-lactamases. |
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Phân loại MIMS
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Đăng xuất
