|
Chỉ định và Liều dùng
Vaginal
Vulvovaginal candidiasis Adult: As 2% cream: Apply approx 5 g intravaginally for 3 consecutive nights or as a single dose.
|
|
Chống chỉ định
Hypersensitivity.
|
|
Thận trọng
Women w/ recurrent infections or those having 1st-time vag yeast infection. Childn <12 yr. Pregnancy and lactation.
|
|
Tác dụng không mong muốn
Vulvovaginal burning, itching, soreness and swelling, pelvic or abdominal pain or cramping. Severe reversible thrombocytopenia. Rarely, headache, urinary frequency and burning, vulvovaginal discharge, irritation, stinging and odor.
|
|
Vag: C
|
|
Thông tin tư vấn bệnh nhân
May weaken latex or rubber products (e.g. condoms, vag contraceptive diaphragms), do not use w/in 72 hr of treatment. Avoid contact w/ eyes.
|
|
Tác dụng
Description:
Mechanism of Action: Butoconazole, a synthetic azole antifungal, is usually fungistatic in action but may have growth phase-dependent fungicidal activity at high concentrations or against very susceptible organisms. It exerts its fungistatic activity by interfering w/ ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against gm+ve organisms. Pharmacokinetics: Absorption: Approx 5% is absorbed after vag use. Excretion: Plasma half-life: 21-24 hr. |
|
Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Butoconazole, CID=47472, https://pubchem.ncbi.nlm.nih.gov/compound/Butoconazole (accessed on Jan. 22, 2020) |
|
Bảo quản
Store between 15-30°C.
|
|
Phân loại MIMS
|
|
Tài liệu tham khảo
Anon. Butoconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/07/2014. Buckingham R (ed). Butoconazole Nitrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/07/2014. Gynazole Cream (Ther-Rx Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/07/2014. McEvoy GK, Snow EK, Miller J et al (eds). Butoconazole Nitrate (Vaginal). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 21/07/2014. Wickersham RM. Butoconazole Nitrate. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 21/07/2014.
|
Đăng xuất
