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Chỉ định và Liều dùng
Oral
Oedema Adult: 5-10 mg daily, may be used with other diuretics. Oral Hypertension Adult: 2.5-7.5 mg daily, may be used with other antihypertensives.
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Chống chỉ định
Severe hepatic impairment and renal decompensation. Addison's disease.
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Thận trọng
Existing fluid and electrolyte disturbances, patients who are at risk from changes in fluid and electrolytes. DM, hypercholesterolaemia, SLE, may precipitate gout.
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Tác dụng không mong muốn
Orthostatic hypotension, Photosensitivity, hypokalaemia, anorexia, epigastric distress.
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Tương tác
Concurrent use with colestipol and cholestyramine may reduce absorption of butizide. Ciclosporin can potentiate the risk of renal toxicity and gout. Efficacy may be reduced by NSAIDs. May enhance toxicity of cardiac glycosides and risk of arrhythmias associated with drugs that prolong QT interval. May increase neuromuscular blocking action of competitive neuromuscular blockers e.g. atracurium. Hypokalaemic effect may be potentiated by corticosteroids, corticotropin, β2 agonists, carbenoxolone, amphotericin B or reboxetine. Concurrent use with lithium may lead to lithium toxicity.
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Tác dụng
Description:
Mechanism of Action: Butizide is a thiazide diuretic that works by inhibiting sodium reabsorption in the distal tubules, resulting in increased excretion of sodium and water as well as potassium and hydrogen ions. It is used in the treatment of oedema and hypertension. |
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Phân loại MIMS
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Đăng xuất
