Bromisoval

Oral
Sedation

Elderly and debilitated patients; young adults, child; depression; pulmonary insufficiency; sleep apnoea; preexisting CNS depression or coma; severe hepatic impairment. Porphyria. Pregnancy and lactation. Elderly and debilitated patients; young adults and childn.

Renal insufficiency; may cause paradoxical excitatory reaction when given to patients in pain unless an analgesic is given concomitantly; may impair ability to drive or operate machinery.

Dependence; drowsiness, sedation, ataxia; resp depression; headache; GI disturbances; skin reactions; confusion and memory defects; paradoxical excitement, irritability; hypersensitivity reactions; haematologic disorders. Nystagmus, miosis, slurred speech and ataxia in excessive doses.
Potentially Fatal: Bromide accumulation and symptoms resembling bromism. Produces neonatal intoxication, vit K deficiency symptoms, congenital malformations when taken during pregnancy.

Sedation or resp depression may be enhanced by drugs with CNS depressants; MAOIs may prolong the CNS depressant effects and also reduce the convulsive threshold, thereby antagonise the anticonvulsant action of barbiturates. Others: Fenoprofen, methadone, pethidine and opioid analgesics; disopyramide, lidocaine and quinidine; chloramphenicol, doxycycline; warfarin and coumarin; antidepressants eg, bupropion, fluoxetine, lithium and mianserin; valproate and progabide; vigabatrin, oxcarbazepine, carbamazepine, clonazepam, ethosuximide, lamotrigine, tiagabine and zonisamide, griseofulvin; teniposide; metronidazole; chlorpromazine; HIV-protease inhibitors; β-blockers; calcium-channel blockers eg, nifedipine and verapamil; digitoxin; ciclosporin; corticosteroids; furosemide; montelukast; oral contraceptives; theophylline; levothyroxine; influenza vaccination and vitamins. Alcohol. St. John's wort.

Description:
Mechanism of Action: Bromisoval has actions and uses similar to carbromal, a bromureide which in turn have general properties similar to barbiturates. It was formerly used for its sedative and hypnotic properties.

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