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Chỉ định và Liều dùng
Topical/Cutaneous
Skin fungal infections Adult: Skin mycoses caused by dermatophytes, yeasts, moulds, and other fungi (e.g. tinea pedis, tinea manuum, tinea corporis, tinea cruris): As 1% cream: Apply thinly onto the affected area(s) once daily, preferably at night. Treatment duration: 2-4 weeks.
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Chống chỉ định
Hypersensitivity. Treatment of nail, scalp and vaginal infections, and infants with diaper rash.
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Thận trọng
Patient with history of hypersensitivity reactions to other imidazole antifungal agents (e.g. clotrimazole, econazole, miconazole). Pregnancy and lactation.
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Tác dụng không mong muốn
Significant: Hypersensitivity reactions.
General disorders and administration site conditions: Application site pain and peripheral oedema. Skin and subcutaneous tissue disorders: Rash, pruritus, erythema, urticaria, dry skin, skin irritation and maceration, skin burning sensation, eczema, blister, skin exfoliation, contact and allergic dermatitis. |
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Thông tin tư vấn bệnh nhân
Avoid contact with eyes and mucous membranes.
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Tương tác
May possibly lead to an increase in INR of warfarin.
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Tác dụng
Description:
Mechanism of Action: Bifonazole is an imidazole derivative broad spectrum antifungal agent. It inhibits the biosynthesis of ergosterol, thereby resulting in structural and functional impairment of the cytoplasmic membrane. Pharmacokinetics: Absorption: Well absorbed into infected skin layers; increased in inflamed skin. Excretion: Via urine (45%); faeces (40%). Elimination half-life: Biphasic: 8 hours and 50 hours. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2378, Bifonazole. https://pubchem.ncbi.nlm.nih.gov/compound/2378. Accessed July 27, 2022. |
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Bảo quản
Store below 30°C.
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Phân loại MIMS
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Phân loại ATC
D01AC10 - bifonazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
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Tài liệu tham khảo
Anon. Bifonazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/07/2022. Buckingham R (ed). Bifonazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/07/2022. Canesten Bifonazole Once Daily 1% w/w Cream (Bayer plc). MHRA. https://products.mhra.gov.uk. Accessed 04/07/2022. Canesten Extra (Bayer HealthCare Limited). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 04/07/2022.
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