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Chỉ định và Liều dùng
Oral
Hyperuricaemia with gout Adult: 50-200 mg daily.
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Cách dùng
Should be taken with food.
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Chống chỉ định
Severe or moderate renal impairment. Patients with uric acid renal calculi, urinary uric acid excretion rates >700 mg/24 hr.
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Thận trọng
May exacerbate and prolong acute gout; start treatment only after acute attack has subsided. Adequate fluid intake should be maintained. Monitor liver function.
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Tác dụng không mong muốn
GI effects; acute attack of gout, uric acid renal calculi, renal colic. May cause liver damage.
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Tương tác
Efficacy may be antagonised when used with aspirin and other salicylates. May increase the activity of coumarin oral anticoagulants.
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Tác dụng
Description:
Mechanism of Action: Benzbromarone reduces plasma concentrations of uric acid by blocking renal tubular reabsorption and possibly by increasing intestinal elimination of uric acid. Pharmacokinetics: Absorption: Partially absorbed from the GI tract. Distribution: Extensively bound to plasma proteins. Metabolism: Metabolised in the liver. Excretion: Mainly excreted in the faeces, a small amount appears in the urine. |
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Phân loại MIMS
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