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Chỉ định và Liều dùng
Oral
Hypertension Adult: Initially, 5-10 mg once daily, may increase dose according to response. Usual maintenance: 10-20 mg once daily.
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Cách dùng
May be taken with or without food.
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Chống chỉ định
Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis.
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Thận trọng
Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischaemic pain following admin. Pregnancy, lactation.
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Tác dụng không mong muốn
Dizziness; flushing; headache; hypotension; peripheral oedema; tachycardia; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression; ischaemic chest pain; cerebral or myocardial ischaemia; transient blindness; rashes; fever; abnormal liver function; gingival hyperplasia; myalgia; tremor; impotence.
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Tương tác
Other antihypertensives; aldesleukin; antipsychotics that cause hypotension; may modify insulin and glucose responses; quinidine; carbamazepine; phenytoin; rifampicin; cimetidine; erythromycin.
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Ảnh hưởng đến kết quả xét nghiệm
Falsely elevated spectrophotometric values of urinary vanillylmandelic acid.
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Tác dụng
Description:
Mechanism of Action: Barnidipine is a dihydropyridine calcium-channel blocker. It is a peripheral and coronary vasodilator, but has little or no effect on cardiac conduction and -ve inotropic activity is rarely seen at therapeutic doses. admin primarily results in vasodilatation, with reduced peripheral resistance, BP, and afterload, increased coronary blood flow, and a reflex increase in heart rate. This results in an increase in myocardial O2 supply and cardiac output. |
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Phân loại MIMS
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Đăng xuất
