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Chỉ định và Liều dùng
Intravenous
Thromboembolic disorders Adult: 30 u over 5 minutes as a single inj, as soon as possible after onset of symptoms.
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Chống chỉ định
Increased risk of cerebral bleeding including severe hypertension, haemorrhage, recent stroke. Cerebral neoplasm, pregnancy.
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Thận trọng
Patients with increased risk of bleeding. Active internal bleeding, recent history of peptic ulcer, esophageal varices, ulcerative colitis, other bleeding GI lesions, pancreatitis, subacute bacterial endocarditis, coagulation defects, invasive procedures, mitral stenosis associated with atrial fibrillation. Elderly, diabetic retinopathy.
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Tác dụng không mong muốn
Allergic reactions; fever; nausea and vomiting; haemorrhage; hypotension; pulmonary embolism, acute renal failure, Gullain-Barre syndrome.
Potentially Fatal: Severe internal bleeding. |
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Tương tác
Increased risk of haemorrhage with heparin, oral anticoagulants, antiplatelet drugs and other drugs that can affect platelet function.
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Tác dụng
Description:
Mechanism of Action: Anistreplase consists of a complex of the lys-form of plasminogen and streptokinase with the addition of a p-anisoyl group that undergoes deacylation upon iv Inj to release the active complex which converts plasminogen to plasmin which has fibrinolytic activity. |
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Phân loại MIMS
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Đăng xuất
