Alverine

Oral
Gastrointestinal tract spasm

Oral
Primary dysmenorrhoea

Paralytic ileus, intestinal obstruction.

Patient with nausea or vomiting, anorexia, weight loss, pallor, fatigue, fever, blood from the bowel, severe constipation, dysuria, and abnormal vaginal discharge or bleeding. Children. Pregnancy and lactation.

Significant: Jaundice (reversible); abnormal LFTs.
Gastrointestinal disorders: Nausea.
Hepatobiliary disorders: Hepatitis (reversible).
Immune system disorders: Hypersensitivity reaction, anaphylaxis.
Nervous system disorders: Headache, dizziness.
Respiratory, thoracic and mediastinal disorders: Dyspnoea, wheezing.
Skin and subcutaneous tissue disorders: Rash, pruritus.

This drug may cause dizziness, if affected, do not drive or operate machinery.

Symptoms: Atropine-like effects and hypotension. Management: Supportive treatment for hypotension. Manage atropine-like effects as for atropine poisoning.

Description:
Mechanism of Action: Alverine is an antispasmodic agent that directly acts on the intestinal and uterine smooth muscles, without affecting the heart, blood vessels and tracheal muscles.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-1.5 hours (PHA).
Metabolism: Rapidly metabolised into para hydroxy alverine (PHA), primary active metabolite; undergoes further conversion to form 2 secondary metabolites.
Excretion: Via urine (as metabolites). Elimination half-life: 0.8 hours (alverine); 5.7 hours (PHA).

Source: National Center for Biotechnology Information. PubChem Database. Alverine, CID=3678, https://pubchem.ncbi.nlm.nih.gov/compound/Alverine (accessed on Jan. 20, 2020)

Store below 25°C. Protect from moisture.

Thuốc chống co thắt

A03AX08 - alverine ; Belongs to the class of other drugs used for functional bowel disorders.

Alverine Citrate 60 mg Hard Capsules (Morningside Healthcare Ltd). MHRA. https://products.mhra.gov.uk. Accessed 06/05/2021.

Anon. Alverine Citrate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/05/2021.

Buckingham R (ed). Alverine Citrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/05/2021.

Joint Formulary Committee. Alverine Citrate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/05/2021.

Spasmonal Forte 120 mg, Hard Capsules (Mylan Products Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 06/05/2021.