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Chỉ định và Liều dùng
Topical/Cutaneous
Corticosteroid-responsive dermatoses Adult: As 0.05% cream/oint: Apply sparingly a thin film onto the affected area 2-3 times daily, for up to 7 days. Longer duration of treatment w/ appropriate monitoring may be necessary in patients w/ resistant or chronic conditions.
Child: ≥1 yr Same as adult dose. Do not use for >3 wk. |
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Chống chỉ định
Broken skin, tuberculous or viral (e.g. herpes simplex, vaccinia, varicella) skin lesions, fungal (e.g. candidiasis, tinea) or bacterial (e.g. impetigo) skin infections, rosacea, acne, perioral dermatitis.
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Thận trọng
Patient w/ seborrhoeic dermatitis, psoriasis. Childn. Pregnancy and lactation.
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Tác dụng không mong muốn
Itching, burning, erythema, dryness, irritation, papular rashes; folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, miliaria, and maceration. Rarely, adrenal suppression, Cushing’s syndrome.
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Topical: C
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Thông tin tư vấn bệnh nhân
Do not apply on the face, eyes, underarm, groin, breast-fold, genitals, or between the toes.
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Chỉ số theo dõi
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression thru ACTH stimulation test, plasma cortisol test, and urinary free cortisol test.
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Quá liều
Symptom: Adrenal insufficiency/hypercorticism (e.g. Cushing’s disease). Management: Symptomatic and supportive treatment. Treat electrolyte imbalance if necessary.
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Tác dụng
Description:
Mechanism of Action: Alclometasone, a synthetic glucocorticoid, induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the biosynthesis and activity of prostaglandins, leukotrienes, and other inflammatory mediators. Pharmacokinetics: Absorption: Approx 3% is absorbed systemically after 8 hr when applied to intact skin. Metabolism: Extensively metabolised into polar, unidentified metabolites. Excretion: Via urine and faeces. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Alclometasone, CID=5311000, https://pubchem.ncbi.nlm.nih.gov/compound/Alclometasone (accessed on Jan. 20, 2020) |
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Bảo quản
Store between 2-30°C.
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Phân loại MIMS
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Phân loại ATC
D07AB10 - alclometasone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
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Tài liệu tham khảo
Alclometasone Dipropionate Ointment. DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 09/08/2016. Anon. Alclometasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/08/2016. Buckingham R (ed). Alclometasone Dipropionate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2016. Joint Formulary Committee. Alclometasone Dipropionate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/08/2016. McEvoy GK, Snow EK, Miller J et al (eds). Alclometasone Dipropionate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 09/08/2016.
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