Miosis during surgery
Adult: As 1% soln: Instill 0.5-2 mL (5-20 mg) directly into the anterior chamber of the eye before or after securing one or more sutures. For prolonged miosis, a 2nd application may be used.
Chỉ định và Liều dùng
Intraocular
Miosis during surgery Adult: As 1% soln: Instill 0.5-2 mL (5-20 mg) directly into the anterior chamber of the eye before or after securing one or more sutures. For prolonged miosis, a 2nd application may be used.
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Hướng dẫn pha thuốc
Reconstitute according to manufacturer’s instructions to produce a 2 mL soln containing acetylcholine 1% and mannitol 2.8%. Prepare the soln immediately before use.
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Thận trọng
Patient w/ anterior/posterior synechiae, asthma, obstructive airway disease, CV disorder (e.g. bradycardia, heart block, recent MI), hypotension, vagotonia, epilepsy, parkinsonism, hyperthyroidism, peptic ulcer.
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Tác dụng không mong muốn
Nausea, vomiting, abdominal pain, salivation, lachrymation, rhinorrhoea, eructation, diarrhoea, urinary frequency, headache, peripheral vasodilation; corneal oedema, clouding, and decompensation, persistent bullous keratopathy, retinal detachment, post-op iritis. Rarely, bradycardia, flushing, hypotension, sweating, dyspnoea, bronchoconstriction.
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Quá liều
Symptoms: Bradycardia, hypotension, flushing, breathing difficulty, sweating. Management: Symptomatic and supportive treatment. Administer atropine sulfate 0.5-1 mg via IV/IM/SC inj. Epinephrine 0.1-1 mg may be beneficial for severe CV or bronchoconstrictor responses.
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Tương tác
Enhanced and prolonged effect w/ cholinesterase inhibitors (e.g. neostigmine). May cause severe bronchospasm w/ subsequent pulmonary oedema and cardiac conduction abnormality w/ β-blockers (e.g. metoprolol). May become ineffective w/ ophth NSAIDs.
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Tác dụng
Description:
Mechanism of Action: Acetylcholine, a quaternary ammonium parasympathomimetic, is an endogenous neurotransmitter released from postganglionic parasympathetic nerves to produce peripheral actions corresponding to muscarine. It stimulates the parasympathetic nervous system causing vasodilation, cardiac depression, miosis, and decrease in intraocular pressure. Additionally, it also has actions that corresponds to nicotine producing stimulant action on skeletal muscle, autonomic ganglia, and adrenal medulla. Onset: Rapid. Duration: Approx 20 min. |
Đặc tính
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Bảo quản
Store between 4-25°C. Do not freeze or resterilise.
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Phân loại MIMS
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Phân loại ATC
S01EB09 - acetylcholine ; Belongs to the class of parasympathomimetics. Used in the treatment of glaucoma and miosis.
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Tài liệu tham khảo
Anon. Acetylcholine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/08/2016. Buckingham R (ed). Acetylcholine Chloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/08/2016. Joint Formulary Committee. Acetylcholine Chloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/08/2016. McEvoy GK, Snow EK, Miller J et al (eds). Acetylcholine Chloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 08/08/2016.
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