Cerebrovascular disorders
Adult: 2-4 mg bid
Oral
Angina pectoris
Adult: 8-16 mg/day
Oral
Hypertension
Adult: 4-16 mg/day; reduce dosage to a max of 8 mg in patients with cirrhosis or on cimetidine.
Indications and Dosage
Oral
Cerebrovascular disorders Adult: 2-4 mg bid Oral Angina pectoris Adult: 8-16 mg/day Oral Hypertension Adult: 4-16 mg/day; reduce dosage to a max of 8 mg in patients with cirrhosis or on cimetidine.
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Contraindications
Cardiogenic shock, recent MI, unstable angina, severe renal impairment, CHF, aortic stenosis.
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Adverse Reactions
Headache, peripheral oedema, dizziness, fatigue, flushing, paradoxical increase in ischaemic chest pain.
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Drug Interactions
Increased hypotensive effects with other antihypertensive drugs such as β-blockers, some antipsychotics, ranitidine, and cimetidine.
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Food Interaction
Increased bioavailability with grapefruit juice.
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Action
Description:
Mechanism of Action: Nilvadipine is a dihydropyridine calcium-channel blocker. It is a peripheral and coronary vasodilator, but has little or no effect on cardiac conduction and negative inotropic activity is rarely seen at therapeutic doses. It results in vasodilatation leading to reduced peripheral resistance, BP, and afterload, increased coronary blood flow, and a reflex increase in heart rate. This results in an increase in myocardial oxygen supply and cardiac output. |
MIMS Class
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