Depression
Adult: Initially, 25 mg bid-tid, gradually increased to 225 mg daily if necessary.
Elderly: Initially, 25 mg daily.
Elderly: Initially, 25 mg daily.
Indications and Dosage
Oral
Depression Adult: Initially, 25 mg bid-tid, gradually increased to 225 mg daily if necessary.
Elderly: Initially, 25 mg daily. |
Contraindications
Preexisting CV insufficiency; severe liver disease; children; overactive patients.
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Special Precautions
Urinary retention, prostatic hypertrophy, untreated angle-closure glaucoma, pheochromocytoma; history of epilepsy; CV disease; impaired liver function; diabetes; risk of suicide; may precipitate mania or psychotic symptoms when used for CNS disorders; withdraw gradually; may impair ability to operate machinery. Pregnancy and lactation. Elderly.
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Adverse Reactions
Restlessness, insomnia, anticholinergic effects, tachycardia, orthostatic hypotension, drowsiness, GI upset, testicular enlargement, impotence. Withdrawal symptoms.
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Drug Interactions
Additive toxicity with antimuscarinics, CNS depressants. Response to TCA may be accelerated with thyroid hormones; pressor effects of sympathomimetics may be enhanced; risk of serotonin syndrome when taken with other antidepressants. Antidiabetic dosage may need to be adjusted.
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Action
Description:
Mechanism of Action: Melitracen is a TCA with anxiolytic properties. |
MIMS Class
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