Thromboembolic disorders
Adult: 200-400 mg/day in 2 divided doses. May also be given parenterally using the sodium salt.
Elderly: >65 yr: 100-200 mg/day.
Elderly: >65 yr: 100-200 mg/day.
Indications and Dosage
Oral
Thromboembolic disorders Adult: 200-400 mg/day in 2 divided doses. May also be given parenterally using the sodium salt.
Elderly: >65 yr: 100-200 mg/day. |
Renal Impairment
100-200 mg/day.
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Contraindications
GI ulceration, ulcerative colitis, active bleeding, haemophilia.
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Special Precautions
Pregnancy, lactation.
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Adverse Reactions
Haemostatic disorders, GI disturbances (diarrhoea, ulcer, bleeding).
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Drug Interactions
Reduced absorption with antacids and cholestyramine.
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Action
Description:
Mechanism of Action: Indobufen inhibits platelet aggregation by reversibly inhibiting the cyclo-oxygenase enzyme, resulting in suppressed thromboxane synthesis. Pharmacokinetics: Absorption: Rapidly absorbed; peak plasma concentrations in 2 hr. Distribution: Protein-binding: 99%. Metabolism: Hepatic. Excretion: Via urine (75%, as metabolites and unchanged drug); 8 hr (plasma half-life). |