Oesophageal candidiasis
Adult: ≤40 kg: 3 mg/kg once daily; >40 kg: 150 mg once daily. Treatment should be given for at least 1 week after resolution of symptoms. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Child: ≥4 months ≤30 kg: 3 mg/kg once daily; >30 kg: 2.5 mg/kg once daily (Max: 150 mg daily). All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Child: ≥4 months ≤30 kg: 3 mg/kg once daily; >30 kg: 2.5 mg/kg once daily (Max: 150 mg daily). All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Intravenous
Prophylaxis of candidiasis
Adult: In patients undergoing haematopoietic stem cell transplantation or those who are expected to have neutropenia for 10 days or more: ≤40 kg: 1 mg/kg once daily; >40 kg 50 mg once daily. Treatment should be given for at least 1 week after recovery of neutrophil. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Child: In patients undergoing haematopoietic stem cell transplantation or those who are expected to have neutropenia for 10 days or more: <4 months 2 mg/kg once daily; ≥4 months Same as adult dose. Treatment should be given for at least 1 week after recovery of neutrophil. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Neonate: In patients undergoing haematopoietic stem cell transplantation or those who are expected to have neutropenia for 10 days or more: 2 mg/kg once daily given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Child: In patients undergoing haematopoietic stem cell transplantation or those who are expected to have neutropenia for 10 days or more: <4 months 2 mg/kg once daily; ≥4 months Same as adult dose. Treatment should be given for at least 1 week after recovery of neutrophil. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Neonate: In patients undergoing haematopoietic stem cell transplantation or those who are expected to have neutropenia for 10 days or more: 2 mg/kg once daily given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Intravenous
Invasive candidiasis
Adult: For the treatment of candidemia and other Candida infections: ≤40 kg: 2 mg/kg once daily for at least 14 days, may increase to 4 mg/kg once daily if response is inadequate; >40 kg: 100 mg once daily for at least 14 days, may increase to 200 mg once daily if response is inadequate. Continue treatment for at least 1 week after obtaining 2 sequential negative blood cultures and after resolution of symptoms. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Child: <4 months 4 mg/kg once daily; may increase up to 10 mg/kg once daily if CNS infection is suspected; ≥4 months Same as adult dose. Continue treatment for at least 1 week after obtaining 2 sequential negative blood cultures and after resolution of symptoms. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Neonate: 4 mg/kg once daily; may increase up to 10 mg/kg once daily if CNS infection is suspected. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Child: <4 months 4 mg/kg once daily; may increase up to 10 mg/kg once daily if CNS infection is suspected; ≥4 months Same as adult dose. Continue treatment for at least 1 week after obtaining 2 sequential negative blood cultures and after resolution of symptoms. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).
Neonate: 4 mg/kg once daily; may increase up to 10 mg/kg once daily if CNS infection is suspected. All doses are given via IV infusion over approx 1 hour. Treatment and dosing recommendations may vary among individual products and between countries (refer to local treatment guidelines).