Hyaluronidase

Adult: As 1,500 units/mL solution: 1,500 units directly added into the solution to be injected (for SC or IM inj). As 150 units/mL or 200 units/mL solution: 50-300 units (usual dose: 150 units) added into the inj solution.

Adult: As 1,500 units/mL solution: 1,500 units mixed with local anaesthetic solution. In ophthalmology: 15 units/mL mixed with ophthalmic local anaesthetic solution.

Adult: As 1,500 units/mL solution: 1,500 units (dissolved in 1 mL of water for inj or NaCl 0.9% solution) via SC inj into the site prior to infusion setup, or via inj into the tubing of the infusion set (approx 2 cm back from the needle) at the start of infusion. Dose is sufficient for administration of 500-1,000 mL infusion fluid. As 150 units/mL or 200 units/mL solution: 150 units or 200 units respectively, via SC inj before the start of SC fluid administration to facilitate absorption of ≥1,000 mL solution, or via addition into small volumes (up to 200 mL) of SC replacement fluid. Dosage, rate of inj and type of solution used must be individualised. Rate and volume of administration should not exceed those used for IV infusion.

Adult: As 1,500 units/mL solution: 1,500 units (dissolved in 1 mL of water for inj or NaCl 0.9% solution) via local infiltration into the affected area as soon as possible after extravasation.

Adult: As 150 units/mL or 200 units/mL solution: 75 units over each scapula, followed by inj of the contrast medium at the same sites. Patient must be in a prone position during the inj.
Child: Infants and children Same as adult dose.