Type 2 diabetes mellitus
Adult: 12.5-75 mg daily. Doses ≥50 mg daily are given in 2 divided doses.
Indications and Dosage
Oral
Type 2 diabetes mellitus Adult: 12.5-75 mg daily. Doses ≥50 mg daily are given in 2 divided doses.
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Contraindications
Type 1 diabetes mellitus; ketoacidosis; severe infection; trauma; other severe conditions where glibornuride is unlikely to control the hyperglycaemia; renal or hepatic impairment; porphyria; pregnancy; lactation.
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Special Precautions
Elderly, debilitated or malnourished patients; adrenal or pituitary insufficiency. Monitor blood glucose concentration.
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Adverse Reactions
GI disturbances; metallic taste; skin rashes, pruritus, photosensitivity; facial flushing; hypoglycaemia; syndrome of inappropriate secretion of antidiuretic hormone; cholestatic jaundice; Stevens-Johnson syndrome; exfoliative dermatitis; erythema nodosum; increased appetite; wt gain; blood disorders.
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Drug Interactions
Diminished hypoglycaemic effect with adrenaline, aminoglutethimide, chlorpromazine, corticosteroids, diazoxide, oral contraceptives, rifamycins and thiazide diuretics. Increased hypoglycaemic effect with ACE inhibitors, alcohol, allopurinol, some analgesics, azole antifungals, chloramphenicol, cimetidine, clofibrate and related compounds, coumarin anticoagulants, halofenate, heparin, MAOIs, octreotide, ranitidine, sulfinpyrazone, sulfonamides, tetracyclines, tricyclic antidepressants and thyroid hormones. β-blockers increase hypoglycaemia and mask typical sympathetic warning signs.
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Lab Interference
Altered liver enzyme values.
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Action
Description:
Mechanism of Action: Glibornuride acts by stimulating insulin secretion and is effective only when some residual pancreatic β-cell activity is present. |
MIMS Class
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