Pain and inflammation
Adult: 200-400 mg 3-4 times daily.
Child: 10-15 yr: 200 mg tid; 5-9 yr: 100 mg tid.
Child: 10-15 yr: 200 mg tid; 5-9 yr: 100 mg tid.
Indications and Dosage
Oral
Pain and inflammation Adult: 200-400 mg 3-4 times daily.
Child: 10-15 yr: 200 mg tid; 5-9 yr: 100 mg tid. |
Contraindications
Peptic ulceration; hypersensitivity to NSAIDs/aspirin; moderate/severe renal impairment.
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Special Precautions
Liver failure. Drink plenty of fluid to reduce the risk of crystallization in the urinary tract. To be discontinued at the 1st sign of allergic reaction. Patient with infection; haemorrhagic disorders; hypertension; cardiac function; asthma. Pregnancy and lactation.
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Adverse Reactions
Anaphylaxis; hepatotoxicity; nephrotoxicity; GI disturbances; crystallization in the urinary tract; cross-reactivity with floctafenine.
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Drug Interactions
Oral anticoagulants; antivirals; phenytoin; sulfonylurea antidiabetic; methotrexate; cardiac glycosides; ACE inhibitors; diuretics; β-blocker; other NSAIDs; lithium; ciclosporin; tacrolimus; moclobemide. Corticosteroids; antiplatelet drugs, biphosphonates, SSRIs and pentoxifylline increase GI bleeding risk. Avoid alcohol and tobacco.
Potentially Fatal: Quinolones: Convulsion may occur. |
Lab Interference
Thyroid function tests: Lowers serum thyroid hormone levels.
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Action
Description:
Mechanism of Action: Glafenine is an NSAID, from the anthranilic acid derivative. Its high incidence of anaphylactic reactions led to its withdrawal from the market in most countries. |
MIMS Class
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