Fatigue/asthenia, hypophosphatemia, nausea; dyspnea; osteonecrosis of the jaw, hypocalcemia; diarrhea; back pain; peripheral edema; headache; anemia. In bone metastases from solid tumors: Asthenia. In multiple myeloma: Thrombocytopenia, upper resp tract infection, rash; pneumonia. In giant cell bone tumor: Arthralgia & pain in extremity; osteomyelitis, tooth abscess or infection. In hypercalcemia of malignancy: Decreased appetite, vomiting, constipation. Infection; hypomagnesemia, hypokalemia.