GI absorption may be interfered by antacids (containing Ca, Mg or Al), sucralfate, didanosine, metal cations (eg, Fe), & multivit prep w/ Zn or any product containing any of these components. Potential additive effect on QT interval prolongation w/ class IA (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol) antiarrhythmic agents. Disturbances of blood glucose including hyperglycemia & hypoglycemia w/ antidiabetic agent. Possible increased AUC of ciclosporin or tacrolimus. Risk of tendon rupture may be increased particularly in the elderly w/ corticosteroids. Episode of torsades de pointes in patient on hemodialysis w/ fluconazole. Risk of CNS stimulation & convulsive seizures may be increased w/ NSAID. Prolonged elimination t
1/2 & elevated serum levels of theophylline & subsequent increase in risk of theophylline-related adverse reactions. Enhanced effects of warfarin.
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