Adult Serious or complicated infections 200-300 mg/kg IV daily in divided doses. Usual dose: 4 g 6-8 hrly.
Life-threatening infections due to Klebsiella spp or Pseudomonas ≤16 g daily. Max: 24 g/day.
Mild or uncomplicated infections 100-150 mg/kg/day. Usual dose: 2 g 6-8 hrly or 4 g 12 hrly IV.
Prophylaxis of surgical infection 2 g pre-op or when the umbilical cord is clamped in CS followed by at least 2 doses of 2 g intervals of 4-6 hr w/in 24 hr of the procedure.
IV Childn 1 mth-12 yr 100-300 mg/kg/day in 3-4 divided doses.
Neonate >7 days or >2 kg 300 mg/kg/day in 3-4 divided doses,
<7 days or <2 kg 150 mg/kg/day in 3 divided doses. May be administered by slow IV inj over 3-5 min; IV infusion over 20-40 min.
Renal insufficiency CrCl 20-80 mL/min 12 g/1.5 g/day in divided doses or 4 g/500 mg 8 hrly,
<20 mL/min 8 g/1 g/day in divided doses or 4 g/500 mg 12 hrly.