Discontinue use if serious skin reactions are suspected. Not recommended in asymptomatic hyperuricemia; patients whom rate of urate formation is greatly increased eg, malignant disease & its treatment, Lesch-Nyhan syndrome. Increased risk of CV death in gout patients w/ established CV disease. Concurrent prophylaxis w/ NSAID or colchicine is recommended when treatment is initiated. Obtain liver test panel (serum ALT, AST, alkaline phosphatase & total bilirubin) as baseline prior to initiation. Promptly monitor liver tests if symptoms that may indicate liver injury are reported. Exercise caution before driving, using machinery or participating in dangerous activities. Pregnancy & lactation. Childn <18 yr.
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