IM/IV Adult 1-2 g daily as a single dose or in 2 divided doses. Severe infections Up to 4 g daily. Gonorrhea 250 mg single IM dose. Surgical infection prophylaxis 1 g single dose for 0.5-2 hr before surgery, colorectal surgery 2 g. Secondary cases of meningococcal meningitis 250 mg single IM dose. Childn & infant 20-50 mg/kg once daily. Severe infections Up to 80 mg/kg. ChildnSecondary cases of meningococcal meningitis 125 mg single IM dose. Neonates Should not exceed 50 mg/kg daily for >60 min when given IV.
Special Precautions
Avoid use in jaundiced neonates. Overgrowth of nonsusceptible organisms for prolonged use. Pseudomembranous colitis may develop.