May enhance blood glucose lowering effect & susceptibility to hypoglycemia w/ oral antidiabetic agents, ACE inhibitors, pentoxifylline, perhexiline, disopyramide, fibrates, fluoxetine, MAOIs, detropropoxyphene, salicylates, sulfonamides. May reduce blood glucose lowering effect & susceptibility to hyperglycemia w/ corticosteroids, danazol, diazoxide, diuretics, glucagon, INH, OCs, phenothiazine derivatives, somatotrophin, sympathomimetic agents [eg, epinephrine (adrenaline), salbutamol, terbutaline], thyroid hormones, PIs & atypical antipsychotic medications (eg, olanzapine & clozapine). Potentiated or weakened blood glucose lowering effect w/ β-blockers, clonidine, lithium salts or alcohol. May cause hypoglycemia w/ pentamidine. Reduced or absent signs of adrenergic counter-regulation w/ β-blockers, clonidine, guanethidine & reserpine.
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