Adult & adolescent Up to 2 g tid.
Childn Nosocomial infection due to Pseudomonas aeruginosa or Acinetobacter spp Up to 40 mg/kg tid.
Adult Pneumonia including community-acquired & nosocomial pneumonia 500 mg or 1 g every 8 hr.
Bronchopulmonary infection in cystic fibrosis 2 g every 8 hr.
Complicated UTI, intra-abdominal & skin & soft tissue; intra- & post-partum infections 500 mg or 1 g every 8 hr.
Acute bacterial meningitis 2 g every 8 hr.
Febrile neutropenic patient 1 g every 8 hr.
Childn >50 kg Adult dose.
Childn 3 mth-11 yr & up to 50 kg Pneumonia including community-acquired & nosocomial pneumonia 10 or 20 mg/kg every 8 hr.
Bronchopulmonary infection in cystic fibrosis 40 mg/kg every 8 hr.
Complicated UTI, intra-abdominal & skin & soft tissue; intra- & post-partum infections 10 mg or 20 mg/kg every 8 hr.
Acute bacterial meningitis 40 mg/kg every 8 hr.
Febrile neutropenic patient 20 mg/kg every 8 hr.
Renal impairment Dose based on unit doses of 500 mg, 1 g, 2 g every 8 hr:
CrCl 26-50 mL/min 1 u every 12 hr;
10-25 mL/min ½ u every 12 hr;
<10 mL/min ½ u every 24 hr. Administer over approx 15-30 min. Alternatively, doses up to 1 g may be given IV bolus inj over approx 5 min.
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